Vol. 22 No. 3 (2024): Blood Transfusion 3-2024 (May-June)

Defining the breakpoints of hybrid blood group alleles


Key words: blood group genetics, hybrid blood group alleles, predicted phenotype
Publication Date: 2024-05-02



Our understanding of the molecular basis of blood group antigen expression began some 25 years ago with the concept that genetic information could be used to predict a phenotype1,2. Characterization of the alleles and expression of the corresponding antigens continue to be refined. The International Society of Blood Transfusion (ISBT) working party on Red Cell Immunogenetics and Blood Group Terminology develops and maintains guidelines for blood group antigen and allele nomenclature for use in transfusion medicine and related sciences3. Two publications in this issue of Blood Transfusion4,7 underscore the concept that our definition of blood group alleles and their relevance to immunohematology should be mindful of the subtleties of gene architecture. [ ... ]



Gregory A. Denomme - Medical Affairs, Grifols Diagnostic Solutions, San Marcos, and Department of Health Sciences, School of Health Professions, UT Health, San Antonio, TX, United States of America

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