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Analysis of HLA matching between deceased organ donors and cord blood units from a national bank network as a basis for potential platforms for chimerism-based immune tolerance after solid organ transplantation

Authors

Key words: deceased organ donors, cord blood units, human leukocyte antigen system, HLA matching, immune tolerance

Abstract

We report here the results from a collaborative analysis conducted on 1,427 consecutive deceased organ donors in Italy during January 2021 and July 2022, with the aim of describing the actual HLA match between these donors and over 38,000 cord blood units (CBU) stored in the Italian Cord Blood Network. We found that for 71% of organ donors there is at least one fully HLA-matched CBU or a single-mismatched one at the A, B, and DRB1 loci, providing a basis for potential future applications of combined organ-hematopoietic stem cells (here from CBU) for immune tolerance purposes, through the well-known phenomenon of hematopoietic mixed chimerism. Due to current hurdles in harvesting bone marrow from deceased organ donors, CBU may provide a valuable source of HLA-compatible hematopoietic stem cells as well as other cellular populations potentially suitable in the future for immune tolerance clinical applications.

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Authors

Roberto Crocchiolo - ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy https://orcid.org/0000-0001-8473-202X

Letizia Lombardini - Italian National Transplant Centre, National Institute of Health, Rome, Italy

Nicoletta Sacchi - Italian Bone Marrow Donor Registry, E.O. Ospedali Galliera, Genoa, Italy

Ilaria Lombardi - Italian National Transplant Centre, National Institute of Health, Rome, Italy

John Blake - Canadian Blood Service, Ottawa, Canada

David Allan - Canadian Blood Service, Ottawa, Canada

Mohamad Sobh - Canadian Blood Service, Ottawa, Canada

Francesca Puoti - Italian National Transplant Centre, National Institute of Health, Rome, Italy

Silvia Trapani - Italian National Transplant Centre, National Institute of Health, Rome, Italy

Anna Maria Gallina - Italian Bone Marrow Donor Registry, E.O. Ospedali Galliera, Genoa, Italy

Marco Sacchi - Coordinamento Regionale Trapianti, DG Welfare Regione Lombardia, Milan, Italy

Simonetta Pupella - Italian National Blood Centre, National Institute of Health, Rome, Italy

Paola Bergamaschi - Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy

Silvano Rossini - ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy

Massimo Cardillo - Italian National Transplant Centre, National Institute of Health, Rome, Italy

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