Position paper

Blood Transfusion - 4 2021 (July-August)

Management of cerebral and splanchnic vein thrombosis associated with thrombocytopenia in subjects previously vaccinated with Vaxzevria (AstraZeneca): a position statement from the Italian Society for the Study of Haemostasis and Thrombosis (SISET)


Publication Date: 2021-04-15


ChAdOx1 nCOV-19 (Vaxzevria) is a vaccine against SARS-CoV-2 infection (COVID-19) developed by Oxford University and AstraZeneca that uses a replication-deficient chimpanzee adenoviral vector (ChAdOx1) containing the SARS-CoV-2 structural surface glycoprotein antigen (spike protein; nCoV-19) gene1.
Over the last few weeks, there have been several reports of thromboembolic events in subjects who had been administered Vaxzevria in the previous weeks. This led several European countries to decide to suspend its administration or, more recently, to limit it to subjects over 60 years of age. [ … ]



Paolo Gresele - Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy

Marco Marietta - Department of Oncology and Haematology, University Hospital, Modena, Italy

Walter Ageno - Department of Medicine and Surgery, “Insubria” University, Varese, Italy

Rossella Marcucci - Department of Experimental and Clinical Medicine, “Careggi” University Hospital, University of Florence, Florence, Italy

Laura Contino - “A.O. SS. Antonio e Biagio” Hospital, Alessandria, Italy

Marco P. Donadini - Department of Medicine and Surgery, Research Centre on Thromboembolic Disorders and Antithrombotic Therapies, University of Insubria, Varese, Italy

Laura Russo - Department of Immunohaematology and Transfusion Medicine, “Papa Giovanni XXIII” Hospital, Bergamo

Giovanni L. Tiscia - Thrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Foggia, Italy

Gualtiero Palareti - “Arianna Anticoagulazione” Foundation, Bologna, Italy

Armando Tripodi - Fondazione IRCCS “Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi” Haemophilia and Thrombosis Centre and “Fondazione Luigi Villa”, Milan, Italy

Valerio De Stefano - 1Section of Haematology, Department of Radiological and Haematological Sciences, Catholic University, Fondazione Policlinico “A. Gemelli” IRCCS, Rome, Italy

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