Abstract

Background - Elderly populations face an increased risk of anemia, leading to elevated transfusion requirements during surgery, especially major orthopedic procedures. Anemia itself increases the risk of thromboembolic events, thus compounding complications in elderly individuals. Polypharmacy and the prevalent use of oral anticoagulants (OAC), particularly for atrial fibrillation, contribute to bleeding risks in this population. Data available in the literature on the peri-operative management of anemia in patients taking OAC is limited and often heterogeneous.

Materials and methods - This narrative case-based review focuses on the peri-operative management of elderly patients on OAC undergoing major orthopedic surgery. PubMed/Medline was used to search for relevant literature.

Results - With reference to two cases, we critically evaluate the literature, and focus on risk factors, and preventive and therapeutic strategies as fundamental tools to reduce bleeding and correct anemia as soon as possible in elderly patients undergoing major orthopedic surgery.

Discussion - Peri-operative management of these patients, especially those on OAC, requires a balanced approach considering bleeding and thrombotic risks. Intravenous iron therapy and tranexamic acid emerge as valuable strategies in minimizing transfusion requirements and optimizing patients' outcomes.

Downloads

Authors

Elvira Grandone - Obstetrics and Gynaecology Department, University of Foggia, Foggia, Italy; Thrombosis and Hemostasis Unit, Fondazione IRCCS “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Foggia, Italy; Department of Obstetrics Gynaecology and Perinatal Medicine, The First I.M. Sechenov Moscow State Medical University, Moscow, Russia https://orcid.org/0000-0002-8980-9783

Giovanni Tiscia - Thrombosis and Hemostasis Unit, Fondazione IRCCS “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Foggia, Italy

Angelo Ostuni - Immunohaematology and Transfusion Medicine Unit, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Bari, Italy

Francesco Marongiu - Department of Medical Sciences and Public Health, Haemostasis and Thrombosis Unit, University of Cagliari and AOU of Cagliari, Cagliari, Italy

Doris Barcellona - Department of Medical Sciences and Public Health, Haemostasis and Thrombosis Unit, University of Cagliari and AOU of Cagliari, Cagliari, Italy

  • Abstract viewed - 231 times
  • pdf downloaded - 140 times