Abstract

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In Western countries, the number of persons affected by haemoglobinopathies, including sickle cell disease (SCD) and thalassaemia syndromes, is constantly increasing owing to migratory flows from the Middle East and Africa1. Blood transfusion remains a key treatment for many patients with haemoglobinopathies. However, selecting compatible units can be challenging, especially in the case of patients of Sub-Saharan (SSA) descent. In these populations, malaria has provided a major pressure favoring the selection of sickle cell trait and rare blood groups, conferring partial protection against Plasmodium infection. [ … ]

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Authors

Alessandra Berzuini - Department of Transfusion Medicine and Haematology and Lombardy Regional Rare Blood Bank, IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

Barbara Foglieni - Department of Transfusion Medicine and Haematology ASST Lecco, Lecco, Italy

Marta Spreafico - Department of Transfusion Medicine and Haematology ASST Lecco, Lecco, Italy

Alessandro Gerosa - Department of Transfusion Medicine and Haematology ASST Lecco, Lecco, Italy

Nicoletta Revelli - Department of Transfusion Medicine and Haematology and Lombardy Regional Rare Blood Bank, IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

Cinzia Paccapelo - Department of Transfusion Medicine and Haematology and Lombardy Regional Rare Blood Bank, IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

Daniele Prati - Department of Transfusion Medicine and Haematology and Lombardy Regional Rare Blood Bank, IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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