Case report


The first case of hyperfibrinolysis induced by delayed hemolytic transfusion reaction in a trauma patient


Key words: transfusion reaction, hyperfibrinolysis, trauma patient, delayed hemolytic transfusion reaction
Publication Date: 2023-03-21



Although delayed hemolytic transfusion reaction (DHTR) is a rare transfusion reaction, its occurrence is more frequent in trauma patients1 and it is the leading cause of transfusion-associated morbidity and mortality2. Alloimmunization sensitized by previous transfusions or pregnancy and subsequent immune hemolytic reactions to red blood cells (RBC) induces DHTR.
In terms of a hemolytic reaction, one study reported in vitro results that RBC and platelet lysates could enhance or diminish  fibrinolysis3. Similarly, downstream consequences could clinically affect the hemostatic state of the patient. However, to our knowledge, there has been no clinical documentation reporting downstream changes in global coagulation states after DHTR. Among the testing methods, global coagulation tests such as rotational thromboelastometry (ROTEM, Tem International GmbH, München, Germany) or thrombelastography provide details on hemostatic states4. Specifically, in combination with extrinsically activated ROTEM (EXTEM) and a test using aprotinin inhibitor (APTEM) of ROTEM in place of routine coagulation tests, fibrinolysis can be reliably detected5. Here, we report the first case of hyperfibrinolysis detected using ROTEM in a patient with DHTR. This study was conducted in accordance with the Declaration of Helsinki and exempted from review by the ethics committee of Chonnam National University Hospital (CNUH), Gwangju, Korea (CNUH-EXP-2022-399).



Ha Jin Lim - Department of Laboratory Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, Korea

Hyunseok Jang - Division of Trauma, Department of Surgery, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, Korea

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