Case report

Vol. 21 No. 5 (2023): Blood Transfusion 5-2023 (September-October)

Solid tumor transmission from donor to recipient after allogeneic stem cell transplantation: it is rare but it happens!

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Key words: solid tumor, allogeneic stem cell transplantation, donor origin

Abstract

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Introduction

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only therapeutic modality with a curative potential for various hematopoietic diseases. However, long term survivors remain at high risk of late complications, including the development of secondary solid malignancies. There is a limited amount of data, regarding the cell of origin and the pathogenesis of secondary solid malignancies post allo-SCT. Several hypotheses have been proposed such as, de-novo occurrence, progression of an occult pre-existing malignancy, and donor-cell related malignancy1.

In the present manuscript, we report a case of a secondary solid neoplasm developed post allo-SCT in a patient with acute myeloid leukemia (AML). An extensive laboratory evaluation for the elucidation of the origin of neoplastic cells is presented in detail.   

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Authors

Panagiotis Tsirigotis - Second Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

Alexandros Spyridonidis - Department of Bone Marrow Transplantation, University Hospital of Rio Patras, Medical School, University of Patras, Greece

Konstantinos Gkirkas - Second Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

Spiros Chondropoulos - Second Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

Phivi Rondogianni - Nuclear Medicine and PET/CT Department, Evangellismos General Hospital, Athens, Greece

Thomas Thomopoulos - Second Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

Angeliki Karagiannidou - Second Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

Dionysios Vythoulkas - Second Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

Marianna Griniezaki - Second Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

Nikolaos Georgakopoulos - Department of Cytogenetics and Molecular Pathology, Locus Medicus S.A, Athens, Greece

Maria Stamouli - Second Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

Periklis G. Foukas - Second Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

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