Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only therapeutic modality with a curative potential for various hematopoietic diseases. However, long term survivors remain at high risk of late complications, including the development of secondary solid malignancies. There is a limited amount of data, regarding the cell of origin and the pathogenesis of secondary solid malignancies post allo-SCT. Several hypotheses have been proposed such as, de-novo occurrence, progression of an occult pre-existing malignancy, and donor-cell related malignancy1.
In the present manuscript, we report a case of a secondary solid neoplasm developed post allo-SCT in a patient with acute myeloid leukemia (AML). An extensive laboratory evaluation for the elucidation of the origin of neoplastic cells is presented in detail.
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