Abstract

PREVIEW

Dear Sir,
Neutrophils play an important role for the elimination of pathogens during infections. Neutropenia results either from enhanced peripheral neutrophil destruction or decreased neutrophil production. Based on severity, neutropenia is divided in three categories: mild, absolute neutrophil count (ANC) <1,000-1,500 cells/mm3, moderate, ANC <500-1,000 cells/mm3 and severe, ANC <500 cells/mm3.1 Patients with severe neutropenia are at risk of developing life-threatening and even fatal infections2. Severe neutropenia may be a consequence of drug interactions3. Since the first description of drug-dependent neutropenia (DDN) by Kracke (1931), many other drugs have been identified to be involved in the mechanism of neutropenia2. [ ... ]

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Authors

Brian R Curtis - Platelet and Neutrophil Immunology Lab, Blood Research Institute, Versiti BloodCenter of Wisconsin, Milwaukee, WI, United States of America

Stefanie Jehle - Institute for Clinical Immunology, Transfusion Medicine, and Haemostasis, Justus-Liebig- University, Giessen, Germany

Gregor Bein - Institute for Clinical Immunology, Transfusion Medicine, and Hemostasis, Justus-Liebig- University, Giessen, Germany

Behnaz Bayat - Institute for Clinical Immunology, Transfusion Medicine, and Hemostasis, Justus-Liebig- University, Giessen, Germany

Ulrich J Sachs - Institute for Clinical Immunology, Transfusion Medicine, and Hemostasis, Justus-Liebig- University, Giessen, Germany; Department of Thrombosis and Hemostasis, Giessen University Hospital, Giessen, Germany

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