Vol. 21 No. 3 (2023): Blood Transfusion 3-2023 (May-June)

Acute myocardial infarction and blood transfusion: lessons learned from animal models and clinical studies


Key words: transfusion, myocardial infarction, risk, benefit, circulatory overload
Publication Date: 2023-02-24



Bulle et al. analyze the incidence of adverse cardiopulmonary events in an animal model of acute myocardial infarction (MI) and transfusion1. Blood transfusion in patients with acute MI may be indicated to improve oxygen delivery or reduce the risk of bleeding in the setting of anti-platelet agents or therapeutic anticoagulation2,3. Specifically, the management of acute MI may include concurrent administration of thrombolytic, antithrombotic, or antiplatelet therapies around the time of percutaneous coronary revascularization procedures, increasing the risk of bleeding and acute anemia. In addition, chronic anemia is often present in older patients with acute MI, especially in those with chronic kidney disease, congestive heart failure, or a history of coronary artery disease4. [ ... ]



Nareg Roubinian - Division of Research, Kaiser Permanente Northern California, Oakland, CA, United States of America; Vitalant Research Institute, San Francisco, CA, United States of America https://orcid.org/0000-0002-1063-6155

Jeffrey Carson - Rutgers, Robert Wood Johnson Medical School, New Brunswick, NJ, United States of America https://orcid.org/0000-0001-5466-2833

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