Abstract

INTRODUCTION
There is a consensus of agreement among several studies on the negative prognostic impact of anemia on the early outcome of cardiovascular surgery1,2. A growing body of evidence suggests that pre-operative treatment of anemia and iron deficiency with intravenous iron, particularly when administered with erythropoietin, may increase the concentration of hemoglobin (Hb) with a reduced risk of allogeneic blood transfusion3-6. However, current knowledge of the benefits of, and possible harm from, iron administration before cardiac surgery is rather limited4,6 and patient blood management strategies7 are not widely implemented. Importantly, no data on the prevalence and prognostic impact of anemia several weeks after cardiac surgery are available. In the present study, we aimed to investigate the effect of post-operative anemia 1-3 months after surgery on the late survival of patients who had undergone isolated coronary artery bypass grafting (CABG).

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Authors

Fausto Biancari - Heart and Lung Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland; Department of Surgery, Oulu University Hospital and University of Oulu, Oulu, Finland; Department of Medicine, South-Karelia Central Hospital, University of Helsinki, Lappeenranta, Finland

Tuomas Tauriainen - Department of Surgery, Oulu University Hospital and University of Oulu, Oulu, Finland

Qiyao Zhang - Department of Molecular Medicine and Surgery, Department of Cardiac Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Giuseppe Gatti - Division of Cardiac Surgery, Cardio-thoracic and Vascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy

Francesco Santini - Division of Cardiac Surgery, Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy

Marisa De Feo - Department of Cardiothoracic Sciences, Monaldi Hospital, University of Campania “Luigi Vanvitelli”, Naples, Italy

Marco Zanobini - Cardiovascular Department, IRCCS Centro Cardiologico Monzino, Milan, Italy

Timo Mäkikallio - Department of Medicine, South-Karelia Central Hospital, University of Helsinki, Lappeenranta, Finland

Francesco Onorati - Division of Cardiac Surgery, University of Verona Medical School, Verona, Italy

Stefano Rosato - Global Health Department, Italian Health Institute, Rome, Italy

Paola D’Errigo - Global Health Department, Italian Health Institute, Rome, Italy

Giovanni Mariscalco - Department of Cardiovascular Sciences, Clinical Sciences Wing, University of Leicester, Glenfield Hospital, Leicester, United Kingdom

Magnus Dalén - Department of Molecular Medicine and Surgery, Department of Cardiac Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

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