Abstract

Introduction
The Lutheran blood group system consists of 27 antigens carried on a single pass type 1 membrane glycoprotein with five immunoglobulin domains. Lu/B-CAM protein has adhesive properties and may mediate intracellular signaling. Lutheran antibodies are usually of limited clinical relevance and only mild cases of hemolytic disease of the fetus and newborn caused by anti-Lub have been described1. Two explanations have been suggested: either the weak expression of B-CAM in cord blood and the neonate, or the presence of B-CAM protein on placental tissue which may result in adsorption of maternal IgG preventing their transfer to the fetus2

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Authors

Pascal Pedini - EFS PACA-Corse, Marseille, France; Aix Marseille Univ, CNRS, EFS, ADES, Marseille, France

Laurine Laget - EFS PACA-Corse, Marseille, France; Aix Marseille Univ, CNRS, EFS, ADES, Marseille, France

Caroline Izard - EFS PACA-Corse, Marseille, France; Aix Marseille Univ, CNRS, EFS, ADES, Marseille, France

Cécile Menanteau - EFS Ile de France, Centre National de Référence pour les Groupes Sanguins (CNRGS), Paris, France

Sophie Beley - EFS PACA-Corse, Marseille, France; Aix Marseille Univ, CNRS, EFS, ADES, Marseille, France

Thomas Granier - EFS PACA-Corse, Marseille, France; Aix Marseille Univ, CNRS, EFS, ADES, Marseille, France

Christophe Picard - EFS PACA-Corse, Marseille, France; Aix Marseille Univ, CNRS, EFS, ADES, Marseille, France

Pascal Bailly - EFS PACA-Corse, Marseille, France; Aix Marseille Univ, CNRS, EFS, ADES, Marseille, France

Jacques Chiaroni - EFS PACA-Corse, Marseille, France; Aix Marseille Univ, CNRS, EFS, ADES, Marseille, France

Stéphane Mazieres - Aix Marseille Univ, CNRS, EFS, ADES, Marseille, France

Thierry Peyrard - EFS Ile de France, Centre National de Référence pour les Groupes Sanguins (CNRGS), Paris, France; UMR_S1134, BIGR, Inserm, Université Paris Cité, Paris, France

Monique Silvy - EFS PACA-Corse, Marseille, France; Aix Marseille Univ, CNRS, EFS, ADES, Marseille, France

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