The Lutheran blood group system consists of 27 antigens carried on a single pass type 1 membrane glycoprotein with five immunoglobulin domains. Lu/B-CAM protein has adhesive properties and may mediate intracellular signaling. Lutheran antibodies are usually of limited clinical relevance and only mild cases of hemolytic disease of the fetus and newborn caused by anti-Lub have been described1. Two explanations have been suggested: either the weak expression of B-CAM in cord blood and the neonate, or the presence of B-CAM protein on placental tissue which may result in adsorption of maternal IgG preventing their transfer to the fetus2.
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