Abstract

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The AZD1222 vaccine (Astrazeneca, Cambridge, UK) is effective and safe against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1. In real-life experience, cases of vaccine-induced thrombocytopenia and thrombosis (VITT) have been described, with associated high morbidity and mortality rates. Thrombocytopenia and thrombosis in unusual venous sites are the common clinical presentation, but arterial thrombosis has also been described2,3. Some treatment recommendations have been published4. Plasma exchange (PE) has recently been reported to be effective in three patients5. We discuss the case of a patient successfully treated with PE after a severe VITT with atypical arterial involvement.

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Authors

Carlos J. de Miguel-Sanchez - Vascular Neurology Section and Stroke Center, Neurology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain

Miguel Arguello-Tomas - Haematology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain; 3Nephrology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spai

Gloria Perez-Rus - Haematology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain; 3Nephrology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain

Pilar Vazquez-Allen - Vascular Neurology Section and Stroke Center, Neurology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain

Antonia G. Mijaylova-Antonova - Nephrology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain

Fernando Anaya - Nephrology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain

Miguel Lopez-Esteban - Haematology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain

Jose Luis Diez-Martin - Haematology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain

Antonio Carmelo Gil-Nuñez - Vascular Neurology Section and Stroke Center, Neurology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain

Cristina Pascual-Izquierdo - Haematology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain

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