Guidelines

Blood Transfusion - 4 2018 (July - August)

Second-line therapy in paediatric warm autoimmune haemolytic anaemia. Guidelines from the Associazione Italiana Onco-Ematologia Pediatrica (AIEOP)

Authors

Publication Date: 2018-04-13

Abstract

Introduction
Autoimmune haemolytic anaemia (AIHA) is a rare condition in children caused by the presence of auto-antibodies directed against red blood cell surface antigens, leading to premature red cell destruction1,2. It is classified as warm, cold, including cold haemagglutinin disease and paroxysmal cold haemoglobinuria, or mixed, according to the thermal range of the auto-antibody. AIHA can be idiopathic or secondary. The overall annual incidence is reported to be 1-3 cases/100,000 people and approximately 0.2 cases/1,000,000 individuals less than 20 years of age. […]

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Authors

Saverio Ladogana - Paediatric Onco-haematology Unit "Casa Sollievo della Sofferenza" Hospital, IRCCS, San Giovanni Rotondo

Matteo Maruzzi - Paediatric Onco-haematology Unit "Casa Sollievo della Sofferenza" Hospital, IRCCS, San Giovanni Rotondo

Piera Samperi - Paediatric Onco-haematology Unit, Azienda "Policlinico Vittorio Emanuele", Department of Clinical and Experimental Medicine, University of Catania, Catania

Annalisa Condorelli - Paediatric Onco-haematology Unit, Azienda "Policlinico Vittorio Emanuele", Department of Clinical and Experimental Medicine, University of Catania, Catania

Maddalena Casale - Department of Women, Children and General and Specialised Surgery, "Luigi Vanvitelli", University of Campania, Naples

Paola Giordano - Department of Paediatrics "B. Trambusti", Policlinico Hospital "Giovanni XXIII", Bari

Lucia D. Notarangelo - Paediatric Onco-haematology Unit, Children's Hospital "Spedali Civili", Brescia

Piero Farruggia - Paediatric Onco-haematology Unit, "Civico" Hospital, Palermo

Fiorina Giona - Haematology, Department of Cellular Biotechnologies and Haematology, "Sapienza" University, Rome

Agostino Nocerino - Department of Paediatrics, "S. Maria della Misericordia" University Hospital, University of Udine, Udine

Silvia Fasoli - Paediatric Unit, "Carlo Poma" Hospital, Mantua

Maria L. Casciana - Paediatric Unit, "Carlo Poma" Hospital, Mantua

Maurizio Miano - Clinical and Experimental Haematology Unit, "G. Gaslini" Children's Hospital, Genoa

Fabio Tucci - Paediatric Haematology-Oncology Unit, Meyer Paediatric Hospital, Florence

Tommaso Casini - Paediatric Haematology-Oncology Unit, Meyer Paediatric Hospital, Florence

Paola Saracco - Paediatric and Adolescent Science Department, University of Turin. Turin

Wilma Barcellini - Onco-haematology, Physiopathology of Anaemia Unit, IRCCS "Ca' Granda Foundation", Ospedale Maggiore Policlinico, Milan, Italy

Silverio Perrotta - Department of Women, Children and General and Specialised Surgery, "Luigi Vanvitelli", University of Campania, Naples

Giovanna Russo - Paediatric Onco-haematology Unit, Azienda "Policlinico Vittorio Emanuele", Department of Clinical and Experimental Medicine, University of Catania, Catania

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