Abstract

Introduction
The formation of storage lesions, which is caused especially by oxidative stress, is a well-known process associated with prolonged storage of erythrocytes1-3. However, its relevance for patients receiving a transfusion is still under discussion4,5. Erythrocyte concentrates are frequently required by patients managed with extracorporeal circulatory systems, such as a heart-lung machine (HLM), extracorporeal life support, extracorporeal membrane oxygenation or other circulatory support techniques. It was reported that the survival of patients was negatively influenced the longer erythrocyte concentrates were stored at 4 °C prior to transfusion, for example, after heart surgery. […..]

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Authors

Lea Krampen - Department of General Paediatrics, Oncology/Haematology, Children's University Hospital Tübingen

Stefanie Krajewski - Department of Thoracic and Cardiovascular Surgery, University Hospital Tüebingen, Germany

Heike Roth - Department of Thoracic and Cardiovascular Surgery, University Hospital Tüebingen, Germany

Rupert Handgretinger - Department of General Paediatrics, Oncology/Haematology, Children's University Hospital Tübingen

Christian Schlensak - Department of Thoracic and Cardiovascular Surgery, University Hospital Tüebingen, Germany

Gernot Bruchelt - Department of General Paediatrics, Oncology/Haematology, Children's University Hospital Tübingen

Hans P. Wendel - Department of Thoracic and Cardiovascular Surgery, University Hospital Tüebingen, Germany

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