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The comments by Farrugia and Bansal1 on our article2 raise several points that deserve further discussion. One comment was that "the assumption that mortality would be unaffected between the two groups is challengeable"1, and a reference on this point was provided3. [...]

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Authors

Andrea Messori - HTA Unit, ESTAR, Regional Health Service, Florence

Flora Peyvandi - "A. Bianchi Bonomi" Haemophilia and Thrombosis Centre, "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico" and Luigi Villa" Foundation, Milan; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

Sabrina Trippoli - HTA Unit, ESTAR, Regional Health Service, Florence

Roberta Palla - Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

Frits R. Rosendaal - Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands

Pier Mannuccio Mannucci - "A. Bianchi Bonomi" Haemophilia and Thrombosis Centre, "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico" and Luigi Villa" Foundation, Milan; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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