Abstract
Introduction
Haemophilia is an X-linked congenital haemorrhagic disorder characterised by low (or dysfunctional) levels of factor (F) VIII (haemophilia A) or FIX (haemophilia B). Affected females are asymptomatic carriers of the disease and affected males present with the phenotypic disorder characterised by bleeding events (often spontaneous and life-threatening) in the soft tissues and joints. In the most severe forms, bleeding symptoms start early in the neonatal period and may be complicated by arthropathy and the development of FVIII (or FIX) neutralising alloantibodies (inhibitors). [... ]
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