Abstract

Introduction
Haemophilia is an X-linked congenital haemorrhagic disorder characterised by low (or dysfunctional) levels of factor (F) VIII (haemophilia A) or FIX (haemophilia B). Affected females are asymptomatic carriers of the disease and affected males present with the phenotypic disorder characterised by bleeding events (often spontaneous and life-threatening) in the soft tissues and joints. In the most severe forms, bleeding symptoms start early in the neonatal period and may be complicated by arthropathy and the development of FVIII (or FIX) neutralising alloantibodies (inhibitors). [... ]

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Authors

Armando Tripodi - Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Haemophilia and Thrombosis Center and Fondazione Luigi Villa, Milan

Rita C. Santoro - Centre for Haemorrhagic and Thrombotic Diseases, "Pugliese-Ciaccio" Hospital, Catanzaro

Sophie Testa - Department of Laboratory Medicine, Haemostasis and Thrombosis Centre, AO "Istituti Ospitalieri", Cremona

Angelo C. Molinari - Thrombosis and Haemostasis Unit, "Giannina Gaslini" Children's Hospital, Genoa

Sergio Bernardini - Department of Experimental Medicine and Surgery, University of Roma "Tor Vergata", Rome

Maria Golato - Unit of Clinical Pathology, "SS Annunziata" University Hospital, ASL Lanciano-Vasto-Chieti, Chieti

Giuseppe Lippi - Section of Clinical Biochemistry, University of Verona, Verona

Walter Ageno - Research Centre on Thromboembolic Diseases and Antithrombotic Therapies, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy

Elena Santagostino - Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Haemophilia and Thrombosis Center and Fondazione Luigi Villa, Milan

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