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PLASTIC RECONSTRUCTIVE AND REGENERATIVE SURGERY

Editorial

Blood Transfusion - 4 2019 (July-August)

Diversity in a blood bag: application of omics technologies to inform precision transfusion medicine

Authors

Tamir Kanias , Michael P. Busch

DOI: 10.2450/2019.0056-19
Publication Date: 2019-06-05

Abstract

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In recent years, red blood cells (RBCs) have finally received well-deserved attention from scientists in the field of transfusion medicine. These biconcave-shaped oxygen-carrying cells were often ignored by cell biologists for being "too simple", due to their lack of intracellular organelles and DNA, and for being relatively unresponsive to their external environment. They were often regarded as an annoying source of contamination from haemoglobin when processing tissues or isolating white blood cells. Special attention was given to studies of RBC response to cold storage and cryopreservation, which gave rise to the widely used, and perhaps obsolete, term of "the RBC storage lesion". [ … ]

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Authors

Tamir Kanias - for the National Heart, Lung, and Blood Institute Recipient Epidemiology Donor Evaluation Study III (REDS-III) Programm; Vitalant Research Institute, Denver, CO

Michael P. Busch - for the National Heart, Lung, and Blood Institute Recipient Epidemiology Donor Evaluation Study III (REDS-III) Programme; Vitalant Research Institute, San Francisco, CA; Department of Laboratory Medicine, University of California, San Francisco, CA, United States of America

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