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PLASTIC RECONSTRUCTIVE AND REGENERATIVE SURGERY

Abstract

A 35-year-old woman presented with symptoms of anemia and hemoglobin of 5.5 g/dL. The patient's blood sample was subjected to standard serological blood grouping, using both tube and column agglutination techniques. Group I discrepancy was found between cell grouping (O Rh D positive) and serum grouping (A group). Serological tests revealed no detectable H antigen on red cells despite presence of normal ABO antigens in the secretions, indicating a para-Bombay Ah secretor phenotype. Blood group genotyping revealed homozygosity for both the FUT1 c.328G>A mutation and the FUT2 c.357C>T mutation, leading to diminished H antigen expression in RBC and intact secretor function, respectively. This rare case of para-Bombay (Ah) secretor phenotype expands the spectrum of H-deficient phenotype reported from India and highlights complexity of blood group typing and importance of molecular diagnostics in rare phenotypes.

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Authors

Thamizhsurabi Arivazhagan - Department of Transfusion Medicine, ESIC Medical College Hospital, Hyderabad, India https://orcid.org/0009-0006-5771-5404

Tejaswi Chada - Department of Transfusion Medicine, ESIC Medical College Hospital, Hyderabad, India https://orcid.org/0000-0001-6807-7213

Srinivasa Rao Chunchu - Department of Transfusion Medicine, ESIC Medical College Hospital, Hyderabad, India https://orcid.org/0000-0002-3989-1432

Monali Lokhande - Department of Transfusion Medicine, ICMR-National Institute of Immunohematology, Mumbai, India https://orcid.org/0009-0003-8518-1858

Rati Devendra - Department of Transfusion Medicine, ICMR-National Institute of Immunohematology, Mumbai, India https://orcid.org/0000-0003-0185-0990

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