Abstract

Introduction
Immune-mediated disorders can be transferred to recipients during solid organ transplantation by residual leukocytes from the donor organ. The most common form is passenger lymphocyte syndrome which provokes hemolytic anemia due to anti-A or anti-B produced by the lymphocytes present in the transplanted organ, in the case of ABO incompatibility between the recipient and donor. Transplantation-mediated alloimmune thrombocytopenia (TMAT) is an uncommon form of donor-derived thrombocytopenia following solid organ transplantation. Rarely described, this condition occurs following transplantation from a donor with immune thrombocytopenia (ITP) and may lead to hemorrhagic complications, graft failure, and even death1-3. In this case report, we describe two children who developed severe, life-threatening thrombocytopenia after in situ split liver transplantation from the same donor. [ … ]

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Authors

Yongjun Wang - Department of Blood Transfusion, The Second Xiangya Hospital, Central South University, Hunan, China

Liyao Fu - Department of Blood Transfusion, The Second Xiangya Hospital, Central South University, Hunan, China

Yanhong Bu - Department of Blood Transfusion, The Second Xiangya Hospital, Central South University, Hunan, China

Ningjie Zhang - Department of Blood Transfusion, The Second Xiangya Hospital, Central South University, Hunan, China

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