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PLASTIC RECONSTRUCTIVE AND REGENERATIVE SURGERY

Abstract

When unexpected antibodies recognizing self red blood cell antigens are detected in individuals by a positive direct antiglobulin (DAT) test and with no evidence of haemolytic anaemia, they are called  ”silent red blood cell autoantibodies (SRBCAA)”. The role of placentally transferred allo- or autoantibodies is established but less is known about the antibodies transferred via breast milk. This is a case report of a  36-week premature female neonate born to a 38-year-old G2P1 with SRBCAA. The neonate presented  with anaemia without signs of infection, hemolysis, or blood loss. The mother and neonate DATs were 1+. We identified the presence of an autoantibody against red cell antigens in the mother’s plasma and breast milk. A similar reaction pattern was also observed in the neonate plasma.  The current case highlights the SRBAC detected in plasma and breast milk as a potential cause of haemolytic disease of the newborn.

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Authors

Zorica Radonjić - Department of Blood Transfusion, Dr. Vukan Čupić Institute for Mother and Child Healthcare of Serbia, Belgrade, Serbia https://orcid.org/0009-0000-2067-8968

Jelena Martić - Department of Neonatology, Dr. Vukan Čupić Institute for Mother and Child Healthcare of Serbia, Belgrade, Serbia; University of Belgrade, Faculty of Medicine, Belgrade, Serbia https://orcid.org/0000-0001-8585-9807

Zorica Rakonjac - Department of Neonatology, Dr. Vukan Čupić Institute for Mother and Child Healthcare of Serbia, Belgrade, Serbia https://orcid.org/0000-0002-0623-3388

Nina Korać - Department for Pretransfusion Testing, Blood Transfusion Institute of Serbia, Belgrade, Serbia https://orcid.org/0009-0000-7067-1940

Olivera Šerbić - Department of Blood Transfusion, Dr. Vukan Čupić Institute for Mother and Child Healthcare of Serbia, Belgrade, Serbia https://orcid.org/0009-0009-0941-3366

Martina Blagojević - Department of Blood Transfusion, Dr. Vukan Čupić Institute for Mother and Child Healthcare of Serbia, Belgrade, Serbia https://orcid.org/0009-0003-4878-5177

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