Abstract
Conversely to the stringent evaluation required for adult unrelated donors, variability exists among centers concerning the evaluations on related donors, in particular with respect to thrombophilia screening and management of thrombotic risk. We report here our monocenter experience across the last six years on a series of 99 related stem cell donors of peripheral blood by leukapheresis, confirming the safety of stem cell donation in terms of thromboembolic risk (no events occurred after a follow-up of 352 person-years) and describing a targeted approach of thrombophilia screening among related donors, mirroring that of the adult unrelated setting. Among the donors included in the present study, only one had a clinically significant protein S deficiency requiring prophylactic anticoagulation, which showed to be safe and did not interfere with mobilization and donation. Our findings do not currently indicate the need for additional screening measures. We believe that related donors should be carefully evaluated for any thrombotic risk before donation, upon the shared principle of donor safety as a priority. Further multicenter studies could provide additional insights to potentially harmonize screening practices among the donation centers.
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