Blood Transfusion - 4 2018 (July - August)
Non-invasive foetal RhD genotyping to guide anti-D prophylaxis: an external quality assurance workshop
Authors:  Frederik B. Clausen, Angela N. Barrett, Grethe R. Krog, Kirstin Finning, Morten H. Dziegiel
Pages:  359-362
To cite this article:  Blood Transfus 2018; 16: 359-62
Doi:  10.2450/2017.0329-16
Published online:  05/04/2017

Alloimmunisation against the D antigen in pregnant RhD-negative women is preventable using anti-D immune prophylaxis1. A combination of antenatal and postnatal anti-D administration has dramatically reduced alloimmunisation of RhD negative women from 16% to 0.3%1,2. Analysis of cell-free foetal DNA (cffDNA) circulating in maternal plasma facilitates non-invasive antenatal testing of the foetal RhD genotype at an early gestational age3,4. Knowledge of the foetal RhD type allows targeted use of antenatal prophylaxis, avoiding unnecessary treatment of RhD-negative women who are carrying a RhD-negative foetus, and are thus at no risk of immunisation5. [...]
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