Blood Transfusion - 4 2017 (July - August)
Red blood cell transfusion policy: a critical literature review
Authors:  Massimo Franchini, Giuseppe Marano, Carlo Mengoli, Simonetta Pupella, Stefania Vaglio, Manuel Muñoz, Giancarlo M. Liumbruno
Pages:  307-317
To cite this article:  Blood Transfus 2017; 15: 307-17
Doi:  10.2450/2017.0059-17
Published online:  20/06/2017

The issue of the most appropriate red blood cell transfusion policy has been addressed by a number of randomised controlled trials, conducted over the last decades, comparing the effects on patients' outcome of restrictive blood transfusion strategies (transfusing when the haemoglobin concentration is less than 7 g/dL to 8 g/dL) vs more liberal ones (transfusing when the haemoglobin concentration is less than 9 g/dL to 10 g/dL) in a variety of clinical settings. In parallel, various systematic reviews and meta-analyses have tried to perform pooled analyses of the data from these randomised controlled trials and their results have been utilised by scientific societies to provide recommendations and guidelines on red blood cell transfusion thresholds. All these aspects will be critically discussed in this narrative review.

Keywords: red blood cells, transfusion thresholds, transfusion policy.
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