Blood Transfusion 2/2017 - Thematic issue on "Red blood cell storage and clinical outcomes: new insights" (March-April)
Red blood cell storage and clinical outcomes: new insights
Authors:  Angelo D'Alessandro, Giancarlo M. Liumbruno
Pages:  101-103
To cite this article:  Blood Transfus 2017; 15: 101-3
Doi:  10.2450/2017.0018-17
Published online:  20/02/2017

The Good
Transfusion of packed red blood cells (RBCs) is a life-saving intervention for millions of chronically or massively transfused recipients worldwide every year. After over a century of improvements, ten years ago a highly-debated retrospective clinical paper1 suggested the potential negative association between storage "age of blood" and transfusion outcomes. This controversial observation fuelled the debate about the potential clinical relevance of the so-called storage lesion(s), a wide series of biochemical and morphological alterations RBCs undergo during storage in the blood bank (as extensively reviewed2-5). Ten years later, a series of comprehensive randomised clinical trials (RCTs) have come to an end, providing reassuring evidence about the lack of a detectable difference between fresh blood and standard of care at the limits of the statistical power of these studies6-10. [...]
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