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Blood Transfusion - 4 2015 (October - December) |
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Quantitation of Lan antigen in Lan+, Lan+w and Lan– phenotypes |
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Authors:
Rhiannon S. McBean, Brett Wilson, Yew-Wah Liew, Catherine A. Hyland, Robert L. Flower |
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Pages:
662-665 |
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To cite this article:
Blood Transfus 2015; 13: 662-5 |
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Doi:
10.2450/2015.0262-14 |
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Published online:
26/02/2015 |
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Preview |
Introduction
The Lan antigen (LAN1) is a clinically significant, high-frequency red blood cell (RBC) antigen. Lan was originally described in 1961 and assigned to the LAN blood group system in 20121,2. Lan is currently the only antigen within the LAN blood group system and Lan+, Lan–, Lan+w and Lan+w/– phenotypes have been defined1-4.
The Lan– phenotype is very rare worldwide with a frequency of less than 1% in all populations tested to date2,5,6. For example, a Japanese screening study identified 14 Lan– individuals among 713,384 blood donors, giving a frequency of 0.002%2. Lan– individuals are usually identified due to the detection of anti-Lan during investigations into haemolytic disease of the foetus and newborn7,8 or when serological testing is performed to find compatible blood units for a patient5,9. Transfusion support for Lan– individuals is highly challenging due to the scarcity of both compatible blood and suitable anti-Lan reagents for screening for compatible blood. The first monoclonal anti-Lan antibody (OSK43) was produced in 2012 by Helias et al. and this antibody has proven to be of huge benefit as a reliable reagent for screening for Lan– individuals2. [...] |
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