Blood Transfusion Supplement 3 - Haemophilia Centre Accreditation Systems and Networks of Centres of Expertise for Rare Diseases in Europe and North America (off subscription) (April)
The haemophilia certification system in Canada
Authors:  Davide Matino, Jerry Teitel, David Page, Arun Keepanasseril, Alfonso Iorio, Irwin Walker
Pages:  s531-s541
To cite this article:  Blood Transfus 2014; 12 Suppl 3: s531-41
Doi:  10.2450/2014.0032-14s
Published online:  06/05/2014

Inherited bleeding disorders are caused by the deficiency or dysfunction of plasma proteins required for the development of a physiological hemostatic process1,2. Von Willebrand disease (vWD), haemophilia A and haemophilia B are the most common inherited disorders of hemostasis. In their severe forms, these disorders are life-threatening. However advanced treatment modalities have enabled even severely affected patients to reach the same life expectancy of the general male population at least in high-income countries3,4 . Indeed, after the dramatic events of widespread blood-borne virus transmission in the 1970s-1980s in haemophilic patients, leading to a 35-to-40-year reduction in life expectancy in Canadian patients5, there has been a strong drive towards continuous improvement, primarily in the safety of replacement therapy6. (...)
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