Blood Transfusion - 6 2017 (November - December)
Selection strategies for newly registered blood donors in European countries
Authors:  Ryanne W. Lieshout-Krikke, Dragoslav Domanovic, Wim de Kort, Wolfgang Mayr, Giancarlo M. Liumbruno, Simonetta Pupella, Johann Kurz, Folke Knutson, Sheila MacLennan, Gilles Folléa
Pages:  495-501
To cite this article:  Blood Transfus 2017; 15: 495-501
Doi:  10.2450/2016.0107-16
Published online:  27/09/2016


Two selection strategies for newly-registered blood donors are available: a single-visit selection called the standard selection procedure (SSP), and a two-stage selection named pre-donation and donation screening (PDS). This study reviews the selection strategies for newly-registered donors currently applied in European countries.
Material and methods. We collected data on donor selection procedures, blood donation, laboratory screening and HIV, HCV and HBV positive donors/donations from 2010 to 2013 in 30 European countries by using questionnaires. We grouped the countries according to the applied selection strategy, and for each country, we calculated the 4-year prevalence of confirmed positive results indicating the presence of overall and recent HIV, HCV and HBV infections among first-time and repeat donations and among newly-registered donors.
Results. Most of the 24 countries (80%) apply the SSP strategy for selection of newly-registered donors. Twenty-two countries (73.3%) employ a nucleic acid amplification testing in addition to the mandatory serological screening. The survey confirms a higher overall prevalence of HIV, HCV and HBV infections among first-time donations and newly-registered donors than among repeat donations. In contrast, the prevalence of recently acquired HIV and HCV infections was lower among first-time donations and newly-registered donors than among repeat donations, but higher for recent HBV infections (6.7/105 vs 2.6/105 in the SSP setting and 4.3/105 vs 0.5/105 in one country using PDS). The relatively low numbers of infected donors selected by PDS impeded accurate assessment of the prevalence of recent infections in first-time donations.
Discussion. The data from European countries provide inconclusive evidence that applying PDS reduces the risk of donations being made in the diagnostic window of first-time donors. The impact of PDS on the risk of window-period donations and blood donor management needs further investigation.

Keywords: donors, infectious diseases, screening, selection.
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