Blood Transfusion 2/2017 - Thematic issue on "Red blood cell storage and clinical outcomes: new insights" (March-April)
The 3-phase evolution of stored red blood cells and the clinical trials: an obvious relationship
Authors:  Michel Prudent, Jean-Daniel Tissot, Niels Lion
Pages:  188
To cite this article:  Blood Transfus 2017; 15; 188
Doi:  10.2450/2017.0317-16
Published online:  20/02/2017

Dear Sir, 
Recent clinical trials testing the effect of erythrocyte concentrates (ECs) stored for various periods of time on transfused patients arrived at the conclusion that the transfusion of ECs fresher than standard of care is not beneficial for patients1,2. However, they do not provide data on long-term stored ECs; nor were they powered to collect such data2,3. Whereas the shelf life of ECs has been fixed by gold standards (haemolysis at the end of storage and red blood cell [RBCs] survival rates in the recipient's circulation), a detailed analysis of ex vivo RBC ageing has brought new insights beyond a recurrent 14-day limit. First of all, let's focus on the biology and biochemistry of stored RBCs. [...]
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