Blood Transfusion 2/2017 - Thematic issue on "Red blood cell storage and clinical outcomes: new insights"

Red blood cell proteomics update: is there more to discover?
 
Authors:  Angelo D'Alessandro, Monika Dzieciatkowska, Travis Nemkov, Kirk C. Hansen
Pages:  182-187
To cite this article:  Blood Transfus 2017; 15: 182-7
Doi:  10.2450/2017.0293-16
Published online:  20/02/2017

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Introduction
A great deal of interest has been attracted by back-of-the-envelope calculations suggesting that bacterial cells (recently revised to be ~3.9×1013) outnumber the total number of host cells in the human body (3.0x1013, estimated for a 70 kg "reference man")1,2. Although early estimates of ~2.8×1013 red blood cells (RBC) in adult humans3 seem excessive in comparison to these numbers, it is universally accepted that RBC constitute the most abundant cell type in the body (~2.5×1013) in foetal and post-natal life3. With an average lifespan of 120 days in circulation, every day ~2×1011 RBC are continuously cleared/released in the blood stream3. However, mature RBC are devoid of nuclei and organelles and each mature RBC contains ~270×106 molecules of haemoglobin, accounting for approximately 90% of its dry weight4. It is not, therefore, surprising that RBC have been almost exclusively viewed as simple biological envelopes for circulating haemoglobin, in the light of their lack of nuclei and organelles and their clear and unique role in oxygen transport and gas homeostasis functions. [...]
  
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