Blood Transfusion 2/2017 - Thematic issue on "Red blood cell storage and clinical outcomes: new insights"

Duration of red blood cell storage and inflammatory marker generation
 
Authors:  Caroline Sut, Sofiane Tariket, Ming Li Chou, Olivier Garraud, Sandrine Laradi, Hind Hamzeh-Cognasse, Jerard Seghatchian, Thierry Burnouf, Fabrice Cognasse
Pages:  145-152
To cite this article:  Blood Transfus 2017; 15: 145-52
Doi:  10.2450/2017.0343-16
Published online:  20/02/2017

Preview
Red blood cell (RBC) transfusion is a life-saving treatment for several pathologies. RBCs for transfusion are stored refrigerated in a preservative solution, which extends their shelf-life for up to 42 days. During storage, the RBCs endure abundant physicochemical changes, named RBC storage lesions, which affect the overall quality standard, the functional integrity and in vivo survival of the transfused RBCs. Some of the changes occurring in the early stages of the storage period (for approximately two weeks) are reversible but become irreversible later on as the storage is extended. In this review, we aim to decipher the duration of RBC storage and inflammatory marker generation. This phenomenon is included as one of the causes of transfusion-related immunomodulation (TRIM), an emerging concept developed to potentially elucidate numerous clinical observations that suggest that RBC transfusion is associated with increased inflammatory events or effects with clinical consequence.

Keywords: red blood cell, inflammation, storage.
 
  
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