Blood Transfusion 2/2017 - Thematic issue on "Red blood cell storage and clinical outcomes: new insights" (March-April)
The accumulation of lipids and proteins during red blood cell storage: the roles of leucoreduction and experimental filtration
Authors:  Christopher C. Silliman, Timothy Burke, Marguerite R. Kelher
Pages:  131-136
To cite this article:  Blood Transfus 2017; 15: 131-6
Doi:  10.2450/2017.0314-16
Published online:  20/02/2017

Pre-storage leucoreduction has been universally adopted in most developed countries in Asia, Europe and the Americas. It decreases febrile transfusion reactions, alloimmunisation to HLA antigens, cytomegalovirus exposure, the accumulation of a number of pro-inflammatory mediators in the supernatant, including the accumulation of platelet- and leucocyte-derived proteins and metabolites during routine storage. This review will highlight the lipids and proteins, biological response modifiers (BRMs) that accumulate, their clinical effects in transfused hosts, and methods of mitigation.

Keywords: red blood cells, transfusion, transfusion-related acute lung injury (TRALI), leucoreduction, neutrophils.
Full Text Download Back
Share this article: