Blood Transfusion - 4 2016 (July - August)
Is solvent/detergent plasma better than standard fresh-frozen plasma? A systematic review and an expert consensus document
 
Authors:  Marco Marietta, Massimo Franchini, M. Lucia Bindi, Francesco Picardi, Matteo Ruggeri, Giustina De Silvestro
Pages:  277-286
To cite this article:  Blood Transfus 2016; 14: 277-86
Doi:  10.2450/2016.0168-15
Published online:  17/02/2016

Preview
Background. Only a few studies have compared solvent/detergent plasma (SD-plasma) to standard fresh-frozen plasma (FFP) in terms of efficacy and safety.
Materials and methods. A systematic review was performed in order to develop a consensus document on the use of SD-plasma. Moreover, a pharmacoeconomic study was performed in order to assess whether the use of SD-plasma can be cost-effective with respect to the use of FFP. A multidisciplinary panel used the systematic review and the GRADE methodology to develop evidence-based recommendations on this topic.
Results. Based on moderate to very low quality evidence, the panel developed the following consensus statements: (i) the panel suggested that SD-plasma is safer than FFP; (ii) the panel could not express for or against a greater efficacy of SD-plasma as compared to FFP; (iii) the panel suggested that in patients undergoing liver transplantation SD-plasma can be preferred over FFP; (iv) the panel suggested that SD-plasma can be preferred over FFP in patients with thrombotic thrombocytopenic purpura undergoing plasma-exchange procedures; (v) the panel could not recommend for or against preferring SD-plasma over FFP in critical care patients; and (vi) the panel suggested that the use of SD-plasma can be cost-effective with respect to the use of FFP.
Discussion. Data from additional randomised studies are needed to establish more definitive guidelines on the use of SD-plasma.

Keywords: liver transplantation, TRALI, thrombotic thrombocytopenic purpura, fresh-frozen plasma, SD-plasma.
  
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