Blood Transfusion - 3 2016 (May - June)
Leucoreduction of blood components: an effective way to increase blood safety?
 
Authors:  Maria Bianchi, Stefania Vaglio, Simonetta Pupella, Giuseppe Marano, Giuseppina Facco, Giancarlo M. Liumbruno, Giuliano Grazzini
Pages:  214-27
To cite this article:  Blood Transfus 2016; 14: 214-27
Doi:  10.2450/2015.0154-15
Published online:  16/12/2015

Preview
Over the past 30 years, it has been demonstrated that removal of white blood cells from blood components is effective in preventing some adverse reactions such as febrile non-haemolytic transfusion reactions, immunisation against human leucocyte antigens and human platelet antigens, and transmission of cytomegalovirus. In this review we discuss indications for leucoreduction and classify them into three categories: evidence-based indications for which the clinical efficacy is proven, indications based on the analysis of observational clinical studies with very consistent results and indications for which the clinical efficacy is partial or unproven.

Keywords: blood component transfusion, leucocyte reduction procedures, leucocyte reduction filtration, cost effectiveness, transfusion reactions.
  
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