Blood Transfusion - 1 2016

Coagulopathy and transfusion strategies in trauma. Overwhelmed by literature, supported by weak evidence
Authors:  Daniele Poole
Pages:  3-7
To cite this article:  Blood Transfus 2016; 14: 3-7
Doi:  10.2450/2015.0244-15
Published online:  20/11/2015

The ultimate goal of medical literature is to offer clinicians indications to improve efficacy in treating their patients. Readers, however, often focus on the conclusions of articles and less on design and methods, without verifying whether the study has or has not met two fundamental requirements, i.e. internal and external validity. Ideally, a study meets the internal validity criteria when it eliminates any source of bias. Thus, only random variation and, for example, the treatment under study are responsible for the outcome. On the other hand, a study reaches external validity when its findings can be reliably applied to other contexts. [...]
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