Blood Transfusion - 4 2015 (October - December)
The impact of deep vein thrombosis in critically ill patients: a meta-analysis of major clinical outcomes
Authors:  Alessandra Malato, Francesco Dentali, Sergio Siragusa, Francesco Fabbiano, Yoan K. Kagoma, Maria Boddi, Gian Franco Gensini, Adriano Peris, Mark Crowther, Mariasanta Napolitano
Pages:  559-568
To cite this article:  Blood Transfus 2015; 13: 559-68
Doi:  10.2450/2015.0277-14
Published online:  10/09/2015

Critically ill patients are at high risk of developing venous thromboembolism (VTE) during their stay in the intensive care unit (ICU) because of the presence of several risk factors including premorbid medical and surgical conditions, invasive tests and treatments, prolonged immobility (often exacerbated by sedation or paralysis), vascular injury from indwelling central venous catheters, and acute and chronic renal insufficiency1. In addition, critical illness activates the coagulation cascade which may mediate the increased likelihood of VTE2-5. Thus, even when adequate antithrombotic prophylaxis is used, deep vein thrombosis (DVT) may occur in up to 10% of patients6. VTE in critically ill patients may be associated with significant morbidity, including prolonged requirement for ICU and hospital stay and, potentially, increased mortality7. [...]
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