Blood Transfusion Supplement 1 (off subscription) (January)
Supplementation of fibrinogen concentrate in children with severe acquired hypofibrinogenaemia during chemotherapy for acute lymphoblastic leukaemia: our experience
Authors:  Paola Giordano, Matteo Luciani, Massimo Grassi, Francesco De Leonardis, Valentina Coletti, Nicola Santoro
Pages:  156-157
To cite this article:  Blood Transfus 2014; 12 Suppl 1: s156-7
Doi:  10.2450/2013.0228-12
Published online:  05/03/2013

Dear Sir,
Bleeding and thrombosis are not infrequent problems in children receiving treatment for acute lymphoblastic leukaemia (ALL); these serious complications are associated with the administration of asparaginase, which induces depletion of antithrombin and fibrinogen. Thrombotic complications often make necessary to suspend asparaginase with possible effects on the child's outcome. Thrombocytopenia and low fibrinogen levels increase the risk of bleeding and haemorrhagic complications of ALL therapy and, in particular, of mini-invasive procedures (lumbar puncture, bone marrow aspirate and biopsy, etc.). (...)
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