Blood Transfusion Supplement 4 - Plasma-derived medicinal products: demand and clinical use (off subscription) (September)
Clinical use and the Italian demand for prothrombin complex concentrates
Authors:  Massimo Franchini, Giancarlo M. Liumbruno, Monica Lanzoni, Fabio Candura, Stefania Vaglio, Samantha Profili, Giuseppina Facco, Gabriele Calizzani, Giuliano Grazzini
Pages:  94-100
To cite this article:  Blood Transfus 2013; 11 Suppl 4: s94-100
Doi:  10.2450/2013.015s
Published online:  08/10/2013

Prothrombin complex concentrates (PCCs) are an important plasma-derived therapeutic option for the rapid correction of deficiency of vitamin-K dependent clotting factors1. PCCs are produced by ion-exchange chromatography from the cryoprecipitate supernatant of large plasma pools after removal of antithrombin and factor (F) XI2. Different processing techniques involving ion exchangers permit the production of either three- (i.e., FII, FIX and FX) or four-factor (i.e., FII, FVII, FIX and FX) concentrates with a final overall clotting factor concentration approximately 25 times higher than in normal plasma (Tables I and II)3. To prevent activation of these factors, most PCCs contain heparin. In addition, they may also contain the physiological inhibitors of coagulation protein C and protein S. PCCs are standardised according to their FIX content and are subjected to viral inactivation processes, both by physical (vapour, heating) and chemical (solvent detergent treatment) methods. (...)
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