Blood Transfusion Supplement 4 - Plasma-derived medicinal products: demand and clinical use (off subscription) (September)
Polyvalent immunoglobulins: challenges and perspectives
Authors:  Isabella Quinti, Serelina Coluzzi, Federica Pulvirenti, Alessandro Prezzo, Gabriella Girelli
Pages:  40-44
To cite this article:  Blood Transfus 2013; 11 Suppl 4: s40-4
Doi:  10.2450/2013.008s
Published online:  08/10/2013

Introduction and biological activities of polyvalent immunoglobulins
Over the past 3 decades, administration of pooled human immunoglobulins (IVIGs) which contain a broad range of antibody specificities, originally in use for antibody replacement therapy, has been extended to other clinical conditions due to their  anti-inflammatory and immunomodulatory effects, which were not anticipated when these polyclonal preparations were first developed1. Currently available IVIGs preparations are produced human pools of plasma obtained from several thousand healthy blood donors by using a number of preparatory steps. The large donor pool ensures the diversity of antibody repertoires similar to those present in normal human serum with antibody specificities to a wide spectrum of antigens. (...)
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