Blood Transfusion - 3 2013 (July - September)
Infusible platelet membrane as a platelet substitute for transfusion: an overview
Authors:  Saleh Nasiri
Pages:  337-342
To cite this article:  Blood Transfus 2013; 11: 337-42
Doi:  10.2450/2013.0209-12
Published online:  14/05/2013

Platelets are small, irregularly shaped clear cell fragments in circulating blood; they have a biconvex disc structure with an equatorial diameter of 2-3 µm and are anucleate. Platelets play a dual role in haemostasis. First, they adhere to and aggregate at sites of vascular lesion1,2. Second, the exposure of anionic phospholipids on the surface of activated platelets acts as a catalytic site for the initiation of the coagulation cascade3,4 that will strengthen initial haemostatic plug formation.
Due to the short life-span of platelet concentrates, units of platelets are generally stored in blood banks for 3-5 days, after which they are discarded. This results in a chronic shortage of fresh platelets. In recent years, the demand for standard platelet concentrates has continued to increase. Various approaches are being taken to develop new human platelet products, as possible alternatives to currently available platelet concentrates5,6. (...)
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