Blood Transfusion - 1 2009

Expression of CD27 and CD23 in peripheral blood B lymphocytes
Authors:  Dino Veneri, Riccardo Ortolani, Massimo Franchini, Giuseppe Tridente, Giovanni Pizzolo, Antonio Vella
Pages:  29-34
To cite this article:  Blood Transfus 2009; 7: 29-34
Doi:  10.2450/2008.0007-08
Published online:  19/06/2008

In this study we evaluated the behaviour of naïve B cells (CD23-/CD27-) and memory B cells (CD27+) in the peripheral blood of humans in a large number of cases throughout all ages. B cells were also distinguished in B2 (CD5-) and B-1a cells (CD5 +). Reduction of the absolute number of B lymphocytes, of the percentage of naïve cells (CD23-/CD27-) and the increase of memory cells (CD27+) was detected. The presence in all ages of a small subset of B cells co-expressing CD23 and CD27 was also evidenced, as some leukemic clones, while the majority of CD27+ cells were CD23-.
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